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MTN-045

Protocol Chair(s)
Etima Ongom, Juliane (Protocol Co-Chair)
Minnis, Alexandra (Protocol Chair)

MTN-045 is a cross-sectional study that will include questionnaires with both partners of the couple - individually and together- including a Discrete-Choice Experiment (DCE) that assesses attribute preferences. Post-survey explanatory IDIs will be conducted with a subset of couples (N=20-40). MPT product forms evaluated will be selected based on literature review and consultation with experts on MPT product development and with MTN EC and may include a vaginal ring, a vaginal insert or film, and co-packaged pills.

MTN-044

Protocol Chair(s)
Achilles, Sharon (Protocol Chair)
Chen, Beatrice (Protocol Co-Chair)

MTN-044/IPM 053/CCN019 is a single-site, randomized (1:1), open-label Phase 1 trial. The study will assess the pharmacokinetics and safety of one silicone elastomer vaginal matrix rings containing 200 mg of dapivirine and 320 mg of levonorgestrel. The MTN-044/IPM 053/CCN019 study population consists of healthy, HIV-uninfected, non-pregnant women between 18-45 years of age. The participants will use the vaginal ring either continuously or cyclically (worn for 28 days and taken out for 2 days) for approximately 90 days, and will be followed up for a total duration of approximately 26 weeks.

MTN 2017 Regional Meeting

DescriptionDateSize
Documents
Hotel Accommodation Booking Form (Download) 2017-06-15138.98 KB
MTN 2017 Regional Meeting Agenda (Download) 2017-08-3198.95 KB
MTN Study Summaries (Download) 2017-09-08589.98 KB
Presentations from Plenary Session 1
01: Welcome/State of the Network - Sharon Hillier and Jared Baeten (Download) 2017-09-191.04 MB
02: MTN-023: U.S. Study of Adolescents - Katie Bunge (Download) 2017-09-197.19 KB
03: Hearing from South African Youth - Moushira El-Sahn (Download) 2017-09-199.05 MB
04: What We Will Learn From the Reach Study - Lulu Nair (Download) 2017-09-192.48 MB
Presentations from Plenary Session 2
01: The Unexpected Complexity in Tracing Participants for an OLE - Brenda Gati (Download) 2017-09-191.03 MB
02: Insights from HA (MTN-032) - Krina Reddy (Download) 2017-09-191.71 MB
03: Increasing VIsit Efficiency in HOPE - Nyaradzo Mgodi (Download) 2017-09-197.19 KB
04: From Ring to DREAM - Mariette Malherbe (Download) 2017-09-19498.31 KB
05: The Regulatory Pathway for the Ring - Leonard Solai (Download) 2017-09-19740.12 KB
Presentations from Plenary Session 3
01: Pills Plus: PrEP in Adolescents - Katherine Gill (Download) 2017-09-201.03 MB
02: PrEP Rollout in Kenya - Elizabeth Irungu (Download) 2017-09-207.17 KB
03: PrEP in Young Women in South Africa - Hasina Subedar (Download) 2017-09-207.17 KB
04: Next Generation PrEP?: Injectable & Implantable ARVs - Craig Hendrix (Download) 2017-09-201.06 MB
05: HIV Prevention Research in the New Era - Dhevium Govender (Download) 2017-09-20595.83 KB
Presentations from Plenary Session 4
01: Engaging Men Reporting Anal Sex in Malawi: Lessons from HPTN 075 - Noel Kayange (Download) 2017-09-207.17 KB
02: The Path Ahead for Rectal Microbicides - Craig Hendrix (Download) 2017-09-201.02 MB
03: The Case for Studying the Ring in Pregnant Women - Renee Heffron (Download) 2017-09-201.79 MB
04: Safety and Pharmacokinetics of Dapivirine Ring Use During Lacation - Lisa Noguchi (Download) 2017-09-201.21 MB
05: Why We Need an MPT - Sharon Achilles (Download) 2017-09-20679.43 KB
Presentations from Plenary Session 5
01: Implementing Evidence-Based Counseling Interventions in Biomedical HIV Prevention Studies - Ivan Balan (Download) 2017-09-211.52 MB
02: The COACH Raters Perspective - Video from Lonely Kachenjera (Download) 2017-09-2152.48 KB
03: Integration of COACH Principles into Contraceptive Counselling - Bernadette Madlala (Download) 2017-09-21347.59 KB
04: Incorporating COACH Principles into Contraceptive Counseling - Thesla Palanee-Phillips (Download) 2017-09-212.41 MB
05: Lessons Learned from HOPE Decliners - Chifundo Zimba (Download) 2017-09-21209.53 KB
06: MTN Closing Remarks - Sharon Hillier and Jared Baeten (Download) 2017-09-212.14 MB
Description Date Size
Documents
Hotel Accommodation Booking Form - Download 138.98 KB
MTN 2017 Regional Meeting Agenda - Download 98.95 KB
MTN Study Summaries - Download 589.98 KB
Presentations from Plenary Session 1
01: Welcome/State of the Network - Sharon Hillier and Jared Baeten - Download 1.04 MB
02: MTN-023: U.S. Study of Adolescents - Katie Bunge - Download 7.19 KB
03: Hearing from South African Youth - Moushira El-Sahn - Download 9.05 MB
04: What We Will Learn From the Reach Study - Lulu Nair - Download 2.48 MB
Presentations from Plenary Session 2
01: The Unexpected Complexity in Tracing Participants for an OLE - Brenda Gati - Download 1.03 MB
02: Insights from HA (MTN-032) - Krina Reddy - Download 1.71 MB
03: Increasing VIsit Efficiency in HOPE - Nyaradzo Mgodi - Download 2017-09-19 7.19 KB
04: From Ring to DREAM - Mariette Malherbe - Download 498.31 KB
05: The Regulatory Pathway for the Ring - Leonard Solai - Download 740.12 KB
Presentations from Plenary Session 3
01: Pills Plus: PrEP in Adolescents - Katherine Gill - Download 1.03 MB
02: PrEP Rollout in Kenya - Elizabeth Irungu - Download 2017-09-20 7.17 KB
03: PrEP in Young Women in South Africa - Hasina Subedar - Download 2017-09-20 7.17 KB
04: Next Generation PrEP?: Injectable & Implantable ARVs - Craig Hendrix - Download 1.06 MB
05: HIV Prevention Research in the New Era - Dhevium Govender - Download 595.83 KB
Presentations from Plenary Session 4
01: Engaging Men Reporting Anal Sex in Malawi: Lessons from HPTN 075 - Noel Kayange - Download 2017-09-20 7.17 KB
02: The Path Ahead for Rectal Microbicides - Craig Hendrix - Download 1.02 MB
03: The Case for Studying the Ring in Pregnant Women - Renee Heffron - Download 1.79 MB
04: Safety and Pharmacokinetics of Dapivirine Ring Use During Lacation - Lisa Noguchi - Download 1.21 MB
05: Why We Need an MPT - Sharon Achilles - Download 679.43 KB
Presentations from Plenary Session 5
01: Implementing Evidence-Based Counseling Interventions in Biomedical HIV Prevention Studies - Ivan Balan - Download 1.52 MB
02: The COACH Raters Perspective - Video from Lonely Kachenjera - Download 52.48 KB
03: Integration of COACH Principles into Contraceptive Counselling - Bernadette Madlala - Download 347.59 KB
04: Incorporating COACH Principles into Contraceptive Counseling - Thesla Palanee-Phillips - Download 2.41 MB
05: Lessons Learned from HOPE Decliners - Chifundo Zimba - Download 209.53 KB
06: MTN Closing Remarks - Sharon Hillier and Jared Baeten - Download 2.14 MB

The MTN 2017 Regional Meeting was held September 17-21, 2017 at the Westin Cape Town Hotel, Convention Square, Lower Long Street, Cape Town 8001, South Africa.  Presentations from our plenary sessions are posted below.  Photos from our meeting can be viewed here.

MTN 2017 Annual Meeting

DescriptionDateSize
Documents /Reports
MTN 2017 Meeting Agenda (Download) 2017-03-0985.81 KB
MTN Study Summaries (Download) 2017-03-09472.02 KB
Understanding Consumer Preference for HIV Prevention Products (Download) 2017-06-0539.11 MB
Medidata Rave Training
Medidata Rave Overview (Download) 2017-03-192.01 MB
Transition to MediData Rave (Download) 2017-03-192.5 MB
Presentations from Plenary Session 1
01: Welcome and State of the Network - Sharon Hillier and Jared Baeten (Download) 2017-03-20418.34 KB
02: HOPE: Lessons to Date - Nyaradzo Mgodi and Thesla Palanee (Download) 2017-03-2043.83 KB
03: Counseling for Choice - Ivan Balan (Download) 2017-03-20320.79 KB
04: Dapivirine Ring Development - Zeda Rosenberg (Download) 2017-03-201.65 MB
Presentations from Plenary Session 2
01: PK/PD: Gut vs Genital Tract - Mackenzie Leigh Cottrell (Download) 2017-03-201.74 MB
02: Microbiome Effects on HIV Risk & Inflammation - Douglas Kwon (Download) 2017-03-202.99 MB
03: Behaviors Associated with Change in the Microbiome - Jeanne Marrazzo (Download) 2017-03-205.62 MB
04: What Do We Know About Routes of HIV Exposure in African Women - Elizabeth Brown (Download) 2017-03-2043.83 KB
Presentations from Plenary Session 3
01: The HIV Epidemic in Young Women - Heather Watts (Download) 2017-03-211.9 MB
02: The REACH Study - Rings and PrEP in Young Women - Lulu Nair (Download) 2017-03-212.02 MB
03: REACH Stakeholders Consultations: Giving Voice to Young Women - Mitchell Warren on behalf of Manju Chatani-Gada (Download) 2017-03-212.76 MB
04: Consumer Preference for Prevention Products - Jeffrey Lucas (Download) 2017-03-215.99 MB
Presentations from Plenary Session 4
01: The Critical Need for Data in Pregnancy and Lactating Women - Lynne Mofenson (Download) 2017-03-212.8 MB
02: Barriers and Facilitators of Rectal Microbicide Use - Rebecca Giguere (Download) 2017-03-21352.54 KB
03: Addressing the Gaps Between Products and People at Risk - Albert Liu (Download) 2017-03-213.19 MB
Description Date Size
Documents /Reports
MTN 2017 Meeting Agenda - Download 85.81 KB
MTN Study Summaries - Download 472.02 KB
Understanding Consumer Preference for HIV Prevention Products - Download 39.11 MB
Medidata Rave Training
Medidata Rave Overview - Download 2.01 MB
Transition to MediData Rave - Download 2.5 MB
Presentations from Plenary Session 1
01: Welcome and State of the Network - Sharon Hillier and Jared Baeten - Download 418.34 KB
02: HOPE: Lessons to Date - Nyaradzo Mgodi and Thesla Palanee - Download 43.83 KB
03: Counseling for Choice - Ivan Balan - Download 320.79 KB
04: Dapivirine Ring Development - Zeda Rosenberg - Download 1.65 MB
Presentations from Plenary Session 2
01: PK/PD: Gut vs Genital Tract - Mackenzie Leigh Cottrell - Download 1.74 MB
02: Microbiome Effects on HIV Risk & Inflammation - Douglas Kwon - Download 2.99 MB
03: Behaviors Associated with Change in the Microbiome - Jeanne Marrazzo - Download 5.62 MB
04: What Do We Know About Routes of HIV Exposure in African Women - Elizabeth Brown - Download 2017-03-20 43.83 KB
Presentations from Plenary Session 3
01: The HIV Epidemic in Young Women - Heather Watts - Download 1.9 MB
02: The REACH Study - Rings and PrEP in Young Women - Lulu Nair - Download 2.02 MB
03: REACH Stakeholders Consultations: Giving Voice to Young Women - Mitchell Warren on behalf of Manju Chatani-Gada - Download 2.76 MB
04: Consumer Preference for Prevention Products - Jeffrey Lucas - Download 5.99 MB
Presentations from Plenary Session 4
01: The Critical Need for Data in Pregnancy and Lactating Women - Lynne Mofenson - Download 2.8 MB
02: Barriers and Facilitators of Rectal Microbicide Use - Rebecca Giguere - Download 352.54 KB
03: Addressing the Gaps Between Products and People at Risk - Albert Liu - Download 3.19 MB

The MTN 2017 Annual Meeting was held March 19-22, 2017, at the Bethesda North Marriott Hotel & Conference Center.  Presentations from our Plenary Sessions have been posted below along with other meeting documents.  Photos fro

MTN 2016 Regional Meeting

DescriptionDateSize
Hotel Accommodation Booking Form (Download) 2016-03-31138.68 KB
MTN 2016 Regional Meeting DRAFT Agenda (Download) 2016-09-1496.6 KB
MTN Studies Summary (Download) 2016-09-19488.07 KB
I. Presentations from Plenary Session, Tuesday, September 27, 2016
BUNGE: MTN 023/IPM 030 The US Adolescent Dapivirine Ring Study Project iMatter (Download) 2016-09-27285.05 KB
HOSEK: Adolescents and Oral PrEP: Results and Lessons from ATN 113 (Download) 2016-09-271.46 MB
MCGOWAN: Welcome and State of the Network (Download) 2016-09-27303.07 KB
MENSCH: Vaginal Ring Use in a Phase 3 Microbicide Trial (Download) 2016-09-27294.89 KB
NAIR/NGURE: MTN 034: REACH Reversing the epidemic in Africa with choices in HIV prevention (Download) 2016-09-271.1 MB
II. Presentations from Plenary Session, Wednesday, September 28, 2016
BAETEN: What will HOPE teach us? (Download) 2016-09-281.66 MB
BALAN: Revolutionizing our Counseling Approaches in HOPE, Lessons from MTN-017 (Download) 2016-09-28728.43 KB
MAKANGA: The Kisumu Clinical Research Site (Download) 2016-09-28238.02 KB
MHLANGA: Uptake of IUCDs in ASPIRE (Download) 2016-09-28796.95 KB
MOODLEY: Awareness of Male Partner Circumcision and Women’s Health (Download) 2016-09-28659.77 KB
ROMANO: Moving Toward an MPT (Download) 2016-09-28343.84 KB
VAN DER STRATEN: Are Ring Worries Affecting Use? Findings from the MTN-020/ASPIRE Phase III Dapivirine Ring Trial (Download) 2016-09-28305.77 KB
III. Presentations from Plenary Session, Thursday, September 29, 2016
BEAMON: DREAMS (Download) 2016-09-29996.74 KB
GATI: HIV Prevention Tools: What does the Community Say? (Download) 2016-09-291 MB
MARRAZZO: The Vaginal Microbiome & HIV-1 Acquisition (Download) 2016-09-293.68 MB
MGODI: Antibody Mediated HIV Prevention: The AMP Studies (Download) 2016-09-291.97 MB
TAHA: Bacterial Vaginosis and Risk of HIV-1 Infection (Download) 2016-09-29358.02 KB
Description Date Size
Hotel Accommodation Booking Form - Download 138.68 KB
MTN 2016 Regional Meeting DRAFT Agenda - Download 96.6 KB
MTN Studies Summary - Download 488.07 KB
I. Presentations from Plenary Session, Tuesday, September 27, 2016
BUNGE: MTN 023/IPM 030 The US Adolescent Dapivirine Ring Study Project iMatter - Download 285.05 KB
HOSEK: Adolescents and Oral PrEP: Results and Lessons from ATN 113 - Download 1.46 MB
MCGOWAN: Welcome and State of the Network - Download 303.07 KB
MENSCH: Vaginal Ring Use in a Phase 3 Microbicide Trial - Download 294.89 KB
NAIR/NGURE: MTN 034: REACH Reversing the epidemic in Africa with choices in HIV prevention - Download 1.1 MB
II. Presentations from Plenary Session, Wednesday, September 28, 2016
BAETEN: What will HOPE teach us? - Download 1.66 MB
BALAN: Revolutionizing our Counseling Approaches in HOPE, Lessons from MTN-017 - Download 728.43 KB
MAKANGA: The Kisumu Clinical Research Site - Download 238.02 KB
MHLANGA: Uptake of IUCDs in ASPIRE - Download 796.95 KB
MOODLEY: Awareness of Male Partner Circumcision and Women’s Health - Download 659.77 KB
ROMANO: Moving Toward an MPT - Download 343.84 KB
VAN DER STRATEN: Are Ring Worries Affecting Use? Findings from the MTN-020/ASPIRE Phase III Dapivirine Ring Trial - Download 305.77 KB
III. Presentations from Plenary Session, Thursday, September 29, 2016
BEAMON: DREAMS - Download 996.74 KB
GATI: HIV Prevention Tools: What does the Community Say? - Download 1 MB
MARRAZZO: The Vaginal Microbiome & HIV-1 Acquisition - Download 3.68 MB
MGODI: Antibody Mediated HIV Prevention: The AMP Studies - Download 1.97 MB
TAHA: Bacterial Vaginosis and Risk of HIV-1 Infection - Download 358.02 KB

The MTN 2016 Regional Meeting was held September 25-29, 2016, at the Westin Cape Town Hotel, Cape Town, South Africa.  Presentations from the plenary sessions, when permission was granted, are listed below.  Photos can be viewed here.

MTN-028

Protocol Chair(s)
Liu, Albert (Protocol Chair)
MTN-028 is a Phase I study that seeks to evaluate the safety and systemic and local pharmacokinetics (PK) of vaginal rings (VRs) containing varying dose strengths of the antiretroviral (ARV) drugs Vicriviroc (MK-4176) and MK-2048. The study will enroll approximately 18 women at one U.S. site beginning in mid to late 2015 and will take approximately 6-9 months to conduct.