MTN-020 Publications

Primary Manuscripts

Use of a vaginal Ring containing dapivirine for HIV-1 prevention in women
Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, et al. Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women. N Engl J Med 2016 Dec 1;375(22):2121-32. PMCID:PMC4993693.

Other Key Manuscripts

Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence
Husnik MJ, Heffron R, Hughes JP, Richardson B, van der Straten A, Palanee-Phillips T, Soto-Torres L, Singh D, Mirembe BG, Livant E, Gaffoor Z, Mansoor LE, Siva SS, Dadabhai S, Kiweewa FM, Baeten JM; MTN-020/ASPIRE Study Team. Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence. AIDS Behav 2024 Nov;28(11):3873-3882. PMCID: PMC9924357

Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women using the Dapivirine Vaginal Ring
Stalter RM, Dong TQ, Hendrix CW, Palanee-Phillips T, van der Straten A, Hillier SL, Kiweewa FM, Mgodi NM, Marzinke MA, Bekker LG, Soto-Torres L, Baeten JM, Brown ER; MTN-020/ASPIRE Study Team. Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women using the Dapivirine Vaginal Ring. J Infect Dis 2024 Apr 12;229(4):1158-1165. PMCID: PMC11011174

Acceptability of the dapivirine vaginal ring for HIV-1 prevention among women reporting engagement in transactional sex
Browne EN, Torjesen K, Mirembe BG, Palanee-Phillips T, Jeenarain N, Chitukuta M, Stoner MCD, Mansoor LE, Reddy K, Tauya TT, Naidoo L, Siva S, Richardson B, Dadabhai S, Seyama L, Soto-Torres L, van der Straten A on behalf of the MTN-020/ASPIRE Study Team. Acceptability of the dapivirine vaginal ring for HIV-1 prevention among women reporting engagement in transactional sex. AIDS Care 2024 Jan;36(1):80-86. PMCID: PMC10579446

Brief Report: Dapivirine ring HIV-1 prevention effectiveness for women engaged in vaginal and anal intercourse: insights from mathematical modeling
Peebles K, Brown ER, Hendrix CW, Palanee-Phillips T, van der Straten A, Harkoo I, Reddy K, Mirembe BG, Jeenarain N, Hillier SL, Baeten JM, Barnabas RV; MTN-020/ASPIRE study team. Dapivirine ring HIV-1 prevention effectiveness for women engaged in vaginal and anal intercourse: insights from mathematical modeling. J Acquir Immune Defic Syndr 2023 Feb 1;92(2):122-126. PMCID: PMC9839478

Population-level correlation between incidence of curable sexually transmitted infections and HIV-1 among African women participating in HIV-1 pre-exposure prophylaxis trials
Hunidzarira P, Brown ER, Chirenje ZM, Hillier SL, Marrazzo JM, Palanee-Phillips T, Kiweewa FM, Baeten JM; MTN-003/VOICE and MTN-020/ASPIRE Study Teams. Population-level correlation between incidence of curable sexually transmitted infections and HIV-1 among African women participating in HIV-1 pre-exposure prophylaxis trials. J Infect Dis 2022 Sep 21;226(6):1069-1074.  PMCID: PMC10233491

Patterns of Adherence to a Dapivirine Vaginal Ring for HIV-1 Prevention Among South African Women in a Phase III Randomized Controlled Trial
Browne EN, Brown ER, Palanee-Phillips T, Reddy K, Naidoo L, Jeenarain N, Nair G, Husnik MJ, Singh D, Scheckter R, Soto-Torres L, Baeten JM, van der Straten A; MTN-020/ASPIRE Study Team. Patterns of Adherence to a Dapivirine Vaginal Ring for HIV-1 Prevention Among South African Women in a Phase III Randomized Controlled Trial. J Acquir Immune Defic Syndr 2022 Aug 1;90(4):418-424.

The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence
Stoner MCD, Brown ER, Palanee-Phillips T, Mansoor LE, Tembo T, Nair G, Akello C, Seyama L, Jeenarain N, Naidoo L, Mgodi N, Hunidzarira P, Chitukuta M, van der Straten A; MTN-020 ASPIRE and M-025 HOPE study teams. The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence. AIDS Behav 2021 Dec;25(12):4169-4179. PMCID: PMC8563504

Strategies implemented for accurate dispensing of an investigational new drug in a multi-site HIV prevention clinical trial
Jacobson C, Moodley J, Bhoola A, Sakwa R, Moodley J, Sukdao J, Hurbans N, Maharaj B, Naidoo A, Maclachlan M, Chareka G, Hlahla K, Chadza M; MTN-020/ASPIRE Study Team. Strategies implemented for accurate dispensing of an investigational new drug in a multi-site HIV prevention clinical trial. Contemp Clin Trials Commun 2021 Nov 12;24:100859. PMCID: PMC8605196

Impact and experience of participant engagement activities in supporting dapivirine ring use among participants enrolled in the phase III MTN-020/ASPIRE study
Garcia M, Luecke E, Mayo AJ, Scheckter R, Ndase P, Kiweewa FM, Kemigisha D, Musara P, Mansoor LE, Singh N, Woeber K, Morar NS, Jeenarain N, Gaffoor Z, Gondwe DK, Makala Y, Fleurs L, Reddy K, Palanee-Phillips T, Baeten JM, van der Straten A, Soto-Torres L, Torjesen K. Impact and experience of participant engagement activities in supporting dapivirine ring use among participants enrolled in the phase III MTN-020/ASPIRE study. BMC Public Health. 2021 Nov 8;21(1):2041. PMCID: PMC8576984

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial
Parikh UM, Penrose KJ, Heaps AL, Halvas EK, Goetz BJ, Gordon KC, Hardesty R, Sethi R, Schwarzmann W, Szydlo DW, Husnik MJ, Chandran U, Palanee-Phillips T, Baeten JM, Mellors JW; MTN-020 Study Team. HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial. J Int AIDS Soc 2021 Nov;24(11):e25833. PMCID: PMC8583424

Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention
Husnik MJ, Brown ER, Dadabhai SS, Gaffoor Z, Jeenarain N, Kiweewa FM, Livant E, Mansoor LE, Mirembe BG, Palanee-Phillips T, Singh D, Siva S, Soto-Torres L, van der Straten A, Baeten JM; M. T. N.-020/ASPIRE Study Team. Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention. AIDS Behav 2021 Sep;25(9):2801-2814. PMCID:PMC8577988

Elevated Risk of Bacterial Vaginosis among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study
Peebles K, Kiweewa FM, Palanee-Phillips T, Chappell C, Singh D, Bunge KE, Naidoo L, Makanani B, Jeenarain N, Reynolds D, Hillier SL, Brown ER, Baeten JM, Balkus JE, MTN-020/ASPIRE study team.  Elevated Risk of Bacterial Vaginosis among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study. Clin Infect Dis 2021 Aug 2;73(3):513-520. PMCID: PMC8326546.

Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial
Mayo AJ, Browne EN, Montgomery ET, Torjesen K, Palanee-Phillips T, Jeenarain N, Seyama L, Woeber K, Harkoo I, Reddy K, Tembo T, Mutero P, Tauya T, Chitukuta M, Gati Mirembe B, Soto-Torres L, Brown ER, Baeten JM, van der Straten A; MTN-020/ASPIRE study team. Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial. AIDS Behav 2021 Aug;25(8):2430-2440. PMCID: PMC8222015

Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa
Leslie J, Kiweewa F, Palanee-Phillips T, Bunge K, Mhlanga F, Kamira B, Baeten J, Katz A, Hillier S, Montgomery E; MTN-020/ASPIRE Study Team. Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa. BMC Womens Health 2021 Apr 23;21(1):175. PMCID: PMC8067655

Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV-1 acquisition: a secondary analysis from a randomized, placebo-controlled trial
Brown ER, Hendrix CW, van der Straten A, Kiweewa FM, Mgodi NM, Palanee-Philips T, Marzinke MA, Bekker LG, Soto-Torres L, Hillier SL, Baeten JM; MTN-020/ASPIRE Study Team. Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV-1 acquisition: a secondary analysis from a randomized, placebo-controlled trial. J Int AIDS Soc 2020 Nov;23(11):e25634. PMCID: PMC7673220

Joint modeling of time-varying HIV exposure and infection for estimation of per-act efficacy in HIV prevention trials
Brown ER,  Dominguez Islas CP, Zhang J. Joint modeling of time-varying HIV exposure and infection for estimation of per-act efficacy in HIV prevention trials. Stat Commun Infect Dis 2020 Sep;12(Suppl 1):20190016. PMCID: PMC8204698

Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods
Mishra A, Bůžková P, Balkus JE and Brown ER. Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods. Stat Commun Infect Dis 2020 Jan;12(1):20190010. PMCID: PMC8208830

Impact of Male Partner Involvement on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial
Roberts ST, Nair G, Baeten JM, Palanee-Philips T, Schwartz K, Reddy K, Kabwigu S, Matovu Kiweewa F, Govender V, Gaffoor Z, Singh N, Siva S, Naidoo K, Montgomery ET; for the MTN-020/ASPIRE Team. Impact of Male Partner Involvement on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial. AIDS Behav 2020 May;24(5):1432-1442. PMCID: PMC7162727

Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities
Reddy K, Kelly C, Brown ER, Jeenarain N, Naidoo L, Siva S, Bekker LG, Nair G, Makanani B, Chinula L, Mgodi N, Chirenje Z, Kiweewa FM, Marrazzo J, Bunge K, Soto-Torres L, Piper J, Baeten JM, Palanee-Phillips T; MTN-020/ASPIRE and MTN-003/VOICE Study Teams. Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities. AIDS 2020 Mar 15;34(4):559-567. PMCID: PMC7262458

Brief Report: Anal intercourse, HIV-1 risk, and efficacy in a trial of a dapivirine-containing vaginal ring for HIV-1 prevention
Peebles K, van der Straten A, Palanee-Phillips T, Reddy K, Hillier SL, Hendrix CW, Harkoo I, Mirembe BG, Jeenarain N, Baeten JM, Brown ER. Anal intercourse, HIV-1 risk, and efficacy in a trial of a dapivirine-containing vaginal ring for HIV-1 prevention. J Acquir Immune Defic Syndr 2020 Mar 1;83(3):197-201.  PMCID: PMC7027377

Relationship type and use of the vaginal ring for HIV-1 prevention in the MTN 020/ASPIRE trial
Pleasants E, Tauya T, Reddy K, Mirembe BG, Woeber K, Palanee-Phillips T, Zimba C, Atujuna M, Montgomery ET; MTN-020/ASPIRE Study Team. Relationship type and use of the vaginal ring for HIV-1 prevention in the MTN 020/ASPIRE trial. AIDS Behav 2020 Mar;24(3):866-880. PMCID: PMC6864230

Hygiene, Blood Flow, and Vaginal Overload: Why Women Removed an HIV Prevention Vaginal Ring During Menstruation in Malawi, South Africa, Uganda and Zimbabwe
Duby Z, Katz AWK, Browne EN, Mutero P, Etima J, Zimba CC, Woeber K, Atujuna M, Reddy K, van der Straten A; MTN-020/ASPIRE Study Team. Hygiene, Blood Flow, and Vaginal Overload: Why Women Removed an HIV Prevention Vaginal Ring During Menstruation in Malawi, South Africa, Uganda and Zimbabwe. AIDS Behav 2020 Feb;24(2):617-628. PMCID: PMC6815681

"The state of mind tells me it's dirty": menstrual shame amongst women using a vaginal ring in Sub Saharan Africa
Duby Z, Katz A, Musara P, Nabukeera J, Zimba CC, Woeber K, Palanee-Phillips T, van der Straten A. "The state of mind tells me it's dirty": menstrual shame amongst women using a vaginal ring in Sub Saharan Africa. Women Health 2020 Jan;60(1):72-86.  PMCID: PMC6824969

Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa
Mhlanga FG, Balkus JE, Singh D, Chappell C, Kamira B, Harkoo I, Szydlo D, Mukaka S, Piper J, Hillier SL. Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa. Int Perspect Sex Reprod Health 2019 Dec 17;45:61-69. PMCID: PMC8515488

Negative rumours about a vaginal ring for HIV-1 prevention in sub-Saharan Africa
Chitukuta M, Duby Z, Katz A, Nakyanzi T, Reddy K, Palanee-Phillips T, Tembo T, Etima J, Musara P, Mgodi NM, van der Straten A, MTN-020/ASPIRE Study Team. Negative rumours about a vaginal ring for HIV-1 prevention in sub-Saharan Africa. Cult Health Sex 2019 Nov;21(11):1209-1224. PMCID: PMC6639142

Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study
Chappell CA, Harkoo I, Szydlo DW, Bunge KE, Singh D, Nakabiito C, Mhlanga F, Kamira B, Piper JM, Balkus JE, Hillier SL; CAT and MTN-020/ASPIRE Study Team. Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study.  Contraception 2019 Sep;100(3):214-218. PMCID: PMC6699890

Risk of HIV-1 acquisition among South African women using a variety of contraceptive methods in a prospective study
Palanee-Phillips T, Brown ER, Szydlo D, Matovu Kiweewa F, Pather A, Harkoo I, Nair G, Soto-Torres L, Hillier SL, Baeten JM; MTN-020/ASPIRE Study Team. Risk of HIV-1 acquisition among South African women using a variety of contraceptive methods in a prospective study. AIDS 2019 Aug 1;33(10):1619-1622. PMCID: PMC6636847

Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the MTN-020/ASPIRE Phase III Trial of the Dapivirine Vaginal Ring
Riddler SA, Balkus JE, Parikh UM, Mellors JW, Akello C, Dadabhai S, Mhlanga F, Ramjee G, Mayo AJ, Livant E, Heaps AL, O'Rourke C, Baeten JM; MTN-015; MTN-020/ASPIRE Study Teams. Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the MTN-020/ASPIRE Phase III Trial of the Dapivirine Vaginal Ring. Clin Infect Dis 2019 Jul 18;69(3):523-529. PMCID: PMC6637274

First Impressions Matter: How Initial Worries Influence Adherence to the Dapivirine Vaginal Ring
van der Straten A, Browne EN, Shapley-Quinn MK, Brown ER, Reddy K, Scheckter R, Soto-Torres L, Palanee-Phillips T, Baeten JM, Mensch B; MTN-020/ASPIRE Study Team. First Impressions Matter: How Initial Worries Influence Adherence to the Dapivirine Vaginal Ring. J Acquir Immune Defic Syndr 2019 Jul 1;81(3):304-310. PMCID: PMC6571014

Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial
Sugarman J, Lin L, Baeten JM, Palanee-Phillips T, Brown ER, Matovu Kiweewa F, Mgodi NM, Nair G, Siva S, Seils DM, Weinfurt KP; MTN-020/ASPIRE Study Team.  Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial. AJOB Empir Bioeth 2019 Apr-Jun;10(2):79-87. PMCID: PMC6612263

Vaginal Ring Use in a Phase 3 Microbicide Trial: A Comparison of Objective Measures and Self-reports of Non-adherence in ASPIRE
Mensch BS, Richardson BA, Husnik M, Brown ER, Kiweewa FM, Mayo AJ, Baeten JM, Palanee-Phillips T, van der Straten A; MTN-020/ASPIRE study team. Vaginal Ring Use in a Phase 3 Microbicide Trial: A Comparison of Objective Measures and Self-reports of Non-adherence in ASPIRE. AIDS Behav 2019 Feb;23(2):504-512. PMCID: PMC6374159

Acquisition of Sexually Transmitted Infections among Women Using a Variety of Contraceptive Options: A Prospective Study among High-Risk African Women
Kiweewa FV, Brown E, Mishra A, Nair G, Palanee-Phillips T, Mgodi N, Nakabiito C, Chakhtoura N, Hillier SL, Baeten JM, MTN-020/ASPIRE Study Team. Acquisition of Sexually Transmitted Infections among Women Using a Variety of Contraceptive Options: A Prospective Study among High-Risk African Women. J Int AIDS Soc 2019 Feb;22(2):e25257. PMCID: PMC6393855

Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy
Makanani B, Balkus JE, Jiao Y, Noguchi LM, Palanee-Phillips T, Mbilizi Y, Moodley J, Kintu K, Reddy K, Kabwigu S, Jeenariain N, Harkoo I, Mgodi N, Piper J, Rees H, Scheckter R, Beigi R, Baeten JM. Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy. J Acquir Immune Defic Syndr 2018 Dec 15;79(5):566-572. PMCID: PMC6231990

Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial
Palanee-Phillips T, Roberts ST, Reddy K, Govender V, Naidoo L, Siva S, Gafoor Z, Pather A, Matovu F, Hlahla K, Makanani B, Nair G, Schwartz K, Torjesen K, Brown E, Soto-Torres L, Baeten J, Montgomery ET. Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial. J Acquir Immune Defic Syndr 2018 Dec 15;79(5):580-589. PMCID: PMC6231955

Impact of the Dapivirine Vaginal Ring on Sexual Experiences and Intimate Partnerships of Women in an HIV Prevention Clinical Trial: Managing Ring Detection and Hot Sex
Laborde ND, Pleasants E, Reddy K, Atujuna M, Nakyanzi T, Chitukuta M, Naidoo S, Palanee-Phillips T, Baeten JM, Montgomery ET; MTN-020/ASPIRE Study Team. Impact of the Dapivirine Vaginal Ring on Sexual Experiences and Intimate Partnerships of Women in an HIV Prevention Clinical Trial: Managing Ring Detection and Hot Sex. AIDS Behav 2018 Feb;22(2):437-446.

Performance of a validated risk score to predict HIV-1 acquisition among African women participating in a trial of the dapivirine vaginal ring
Balkus JE, Brown ER, Palanee-Phillips T, Kiweewa FM, Mgodi N, Naidoo L, Mbilizi Y, Jeenarain N, Gaffoor Z, Siva S, Nair G, Pather A, Baeten JM. Performance of a validated risk score to predict HIV-1 acquisition among African women participating in a trial of the dapivirine vaginal ring. J Acquir Immune Defic Syndr 2018 Jan 1;77(1):e8-e10.  PMCID:PMC5720924

Implementation of a Novel Adherence Monitoring Strategy in a Phase III, Blinded, Placebo-Controlled, HIV-1 Prevention Clinical Trial
Husnik MJ, Brown ER, Marzinke M, Livant E, Palanee-Phillips T, Hendrix C, Kiweewa FM, Nair G, Soto-Torres LE, Schwartz K, Hillier SL, Baeten JM; MTN-020 ASPIRE Study Team. Implementation of a Novel Adherence Monitoring Strategy in a Phase III, Blinded, Placebo-Controlled, HIV-1 Prevention Clinical Trial. J Acquir Immune Defic Syndr 2017 Nov 1;76(3):330-337. PMCID: PMC5634926

Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception
Balkus JE, Palanee-Phillips T, Reddy K, Siva S, Harkoo I, Nakabiito C, Kintu K, Nair G, Chappell C, Kiweewa FM, Kabwigu S, Naidoo L, Jeenarain N, Marzinke M, Soto-Torres L, Brown ER, Baeten JM. Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception. J Acquir Immune Defic Syndr 2017 Oct 1;76(2):e47-e51. PMCID: PMC5597463

Favoring “Peace of Mind”: A Qualitative Study of African Women's HIV Prevention Product Formulation Preferences from the MTN-020/ASPIRE Trial
van der Straten A, Shapley-Quinn M, Reddy K, Cheng H, Etima J, Woeber K, Musara P, Palanee-Phillips T, Baeten JM, Montgomery ET, and on behalf of the MTN-020/ASPIRE Study Team. Favoring “Peace of Mind”: A Qualitative Study of African Women's HIV Prevention Product Formulation Preferences from the MTN-020/ASPIRE Trial. AIDS Patient Care and STDs 2017 July ; 31(7): 305-314 PMCID: PMC5512310

Acceptability and use of a dapivirine vaginal ring in a phase III trial
Montgomery ET, van der Straten A, Chitukuta M, Reddy K, Woeber K, Atujuna M, Bekker LG, Etima J, Nakyanzi T, Mayo AJ, Katz A, Laborde N, Grossman CI, Soto-Torres L, Palanee-Phillips T, Baeten JM; MTN-020/ASPIRE Study. Acceptability and use of a dapivirine vaginal ring in a phase III trial. AIDS 2017 May 15;31(8):1159-1167. PMCID: PMC5557083

Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention
Palanee-Phillips T, Schwartz K, Brown ER, Govender V, Mgodi N, et al. Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention.  PLoS ONE 2015;10(6): e0128857.