MTN Publications

Manohar M, Marzinke MA. Validation and implementation of an ultrasensitive liquid chromatographic-tandem mass spectrometric (LC-MS/MS) assay for dapivirine quantitation in breast milk. Clin Biochem 2020;82:66-72. PMCID: PMC6944438

Katz AWK, Naidoo K, Reddy K, Chitukuta M, Nabukeera J, Siva S, Zimba C, Montgomery ET. The Power of the Shared Experience: MTN-020/ASPIRE Trial Participants' Descriptions of Peer Influence on Acceptability of and Adherence to the Dapivirine Vaginal Ring for HIV Prevention. AIDS Behav 2020 Aug;24(8):2387-2399.PMCID: PMC8631948

van der Straten A, Ryan JH, Reddy K, et al. Influences on willingness to use vaginal or oral HIV PrEP during pregnancy and breastfeeding in Africa: the multisite MAMMA study. J Int AIDS Soc 2020;23(6):e25536. PMCID: PMC7287313

Roberts ST, Nair G, Baeten JM, Palanee-Philips T, Schwartz K, Reddy K, Kabwigu S, Matovu Kiweewa F, Govender V, Gaffoor Z, Singh N, Siva S, Naidoo K, Montgomery ET; for the MTN-020/ASPIRE Team. Impact of Male Partner Involvement on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III HIV Prevention Trial. AIDS Behav 2020 May;24(5):1432-1442. PMCID: PMC7162727

Reddy K, Kelly C, Brown ER, Jeenarain N, Naidoo L, Siva S, Bekker LG, Nair G, Makanani B, Chinula L, Mgodi N, Chirenje Z, Kiweewa FM, Marrazzo J, Bunge K, Soto-Torres L, Piper J, Baeten JM, Palanee-Phillips T; MTN-020/ASPIRE and MTN-003/VOICE Study Teams. Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities. AIDS 2020 Mar 15;34(4):559-567. PMCID: PMC7262458

Peebles K, van der Straten A, Palanee-Phillips T, Reddy K, Hillier SL, Hendrix CW, Harkoo I, Mirembe BG, Jeenarain N, Baeten JM, Brown ER. Brief Report: Anal intercourse, HIV-1 risk, and efficacy in a trial of a dapivirine-containing vaginal ring for HIV-1 prevention. J Acquir Immune Defic Syndr 2020 Mar 1;83(3):197-201. PMCID: PMC7027377

Pleasants E, Tauya T, Reddy K, Mirembe BG, Woeber K, Palanee-Phillips T, Zimba C, Atujuna M, Montgomery ET; MTN-020/ASPIRE Study Team. Relationship type and use of the vaginal ring for HIV-1 prevention in the MTN 020/ASPIRE trial. AIDS Behav 2020 Mar;24(3):866-880. PMCID: PMC6864230

Bunge KE, Levy L, Szydlo DW, Zhang J, Gaur AH, Reirden D, Mayer KH, Futterman D, Hoesley C, Hillier SL, Marzinke MA, Hendrix CW, Gorbach PM, Wilson CM, Soto-Torres L, Kapogiannis B, Nel A, Squires KE; MTN-023/IPM 030 Study Team. Brief Report: Phase IIa Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Young Women. J Acquir Immune Defic Syndr 2020 Feb 1;83(2):135-139. PMCID: PMC8577288

Duby Z, Katz AWK, Browne EN, Mutero P, Etima J, Zimba CC, Woeber K, Atujuna M, Reddy K, van der Straten A; MTN-020/ASPIRE Study Team. Hygiene, Blood Flow, and Vaginal Overload: Why Women Removed an HIV Prevention Vaginal Ring During Menstruation in Malawi, South Africa, Uganda and Zimbabwe. AIDS Behav 2020 Feb;24(2):617-628. PMCID: PMC6815681

Bauermeister JA, Golinkoff JM, Carballo-Diéguez A, Giguere R, López D, Hoesley CJ, Chen BA, Anderson P, Dezzutti CS, Strizki J, Sprinkle C, Heard F, Hall W, Jacobson C, Berthiaume J, Mayo A, Richardson BA, Piper J; Microbicide Trials Network 027 Study Team. A Mixed-Methods Study Examining Adherence to and Acceptability of Intravaginal Rings for HIV Prevention: Behavioral Results of MTN-027. AIDS Behav 2020 Feb;24(2):607-616. PMCID:PMC6745293

Baeten JM, Hendrix CW, Hillier SL. Topical Microbicides in HIV Prevention: State of the Promise. Annu Rev Med 2020 Jan 27;71:361-377. PMCID: PMC8038211

Mishra A, Bůžková P, Balkus JE and Brown ER. Accounting for informative sampling in estimation of associations between sexually transmitted infections and hormonal contraceptive methods. Stat Commun Infect Dis 2020 Jan;12(1):20190010. PMCID: PMC8208830

Palanee-Phillips T, Baeten JM. Topical delivery of long-acting antiretrovirals to prevent HIV acquisition. Curr Opin HIV AIDS 2020 Jan;15(1):42-48. PMCID: PMC7325564

Duby Z, Katz A, Musara P, Nabukeera J, Zimba CC, Woeber K, Palanee-Phillips T, van der Straten A. "The state of mind tells me it's dirty": menstrual shame amongst women using a vaginal ring in Sub Saharan Africa. Women Health 2020 Jan;60(1):72-86. PMCID: PMC6824969

Mhlanga FG, Balkus JE, Singh D, Chappell C, Kamira B, Harkoo I, Szydlo D, Mukaka S, Piper J, Hillier SL. Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa. Int Perspect Sex Reprod Health 2019 Dec 17;45:61-69. PMCID: PMC8515488

Montgomery ET, Roberts ST, Nel A, Malherbe M, Torjesen K, Bunge K, Singh D, Baeten JM, Marrazzo J, Chirenje ZM, Kabwigu S, Beigi R, Riddler SA, Gafoor Z, Reddy K, Mansoor LE, Nair L, Woeber K, Moodley J, Jeenarain N, Siva S, Naidoo L, Govender V, Palanee-Phillips T. Social Harms in Female-INITIATED hiv prevention method RESEARCH: state of the evidence. AIDS 2019 Nov 15;33(14):2237-2244. PMCID: PMC6832829

Chitukuta M, Duby Z, Katz A, Nakyanzi T, Reddy K, Palanee-Phillips T, Tembo T, Etima J, Musara P, Mgodi NM, van der Straten A, MTN-020/ASPIRE Study Team. Negative rumours about a vaginal ring for HIV-1 prevention in sub-Saharan Africa. Cult Health Sex 2019 Nov;21(11):1209-1224. PMCID: PMC6639142

Hartmann M, Lanham M, Palanee-Phillips T, Mathebula F, Tolley EE, Peacock D, Pascoe L, Zissette S, Roberts ST, Wagner D, Wilson E, Ayub A, Wilcher R, Montgomery ET; CHARISMA team. Generating CHARISMA: Development of an Intervention to Help Women Build Agency and Safety in Their Relationships While Using PrEP for HIV Prevention. AIDS Educ Prev 2019 Oct;31(5):433-451. PMCID: PMC7082989

Chappell CA, Harkoo I, Szydlo DW, Bunge KE, Singh D, Nakabiito C, Mhlanga F, Kamira B, Piper JM, Balkus JE, Hillier SL; CAT and MTN-020/ASPIRE Study Team. Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study. Contraception 2019 Sep;100(3):214-218. PMCID: PMC6699890

Liu AY, Norwood A, Gundacker H, Carballo-Diéguez A , Johnson S, Patterson K , Gail Bekker L, Chariyalertsak S, Chitwarakorn A, Gonzales P, Holtz TH, Mayer KH, Zorrilla C, Buchbinder S, Piper JM, Lama JR, Cranston RD, On Behalf of the Microbicide Trials Network-017 Team. Routine Use of Oral PrEP in a Phase 2 Rectal Microbicide Study of Tenofovir Reduced-Glycerin 1% Gel (MTN-017). J Acquir Immune Defic Syndr 2019 Aug 15;81(5):516-520. PMCID: PMC6629432

Palanee-Phillips T, Brown ER, Szydlo D, Matovu Kiweewa F, Pather A, Harkoo I, Nair G, Soto-Torres L, Hillier SL, Baeten JM; MTN-020/ASPIRE Study Team. Risk of HIV-1 acquisition among South African women using a variety of contraceptive methods in a prospective study. AIDS 2019 Aug 1;33(10):1619-1622. PMCID: PMC6636847

Simoni JM, Beima-Sofie K, Amico KR, Hosek SG, Johnson MO, Mensch BS. Debrief Reports to Expedite the Impact of Qualitative Research: Do They Accurately Capture Data from In-depth Interviews? AIDS Behav. 2019 Aug;23(8):2185-2189. PMCID: PMC6642848

Riddler SA, Balkus JE, Parikh UM, Mellors JW, Akello C, Dadabhai S, Mhlanga F, Ramjee G, Mayo AJ, Livant E, Heaps AL, O'Rourke C, Baeten JM; MTN-015; MTN-020/ASPIRE Study Teams. Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the MTN-020/ASPIRE Phase III Trial of the Dapivirine Vaginal Ring. Clin Infect Dis 2019 Aug; 69(3), 523–529. PMCID: PMC6637274

van der Straten A, Browne EN, Shapley-Quinn MK, Brown ER, Reddy K, Scheckter R, Soto-Torres L, Palanee-Phillips T, Baeten JM, Mensch B; MTN-020/ASPIRE Study Team. First Impressions Matter: How Initial Worries Influence Adherence to the Dapivirine Vaginal Ring. J Acquir Immune Defic Syndr 2019 Jul 1;81(3):304-310. PMCID: PMC6571014

Caplan MR, Landovitz RJ, Palanee-Phillips T, Nair G, Mhlanga F, Balkus JE, Riddler SA, Gorbach PM. Complex decisions: correlates of injectable contraceptive discontinuation following HIV-1 seroconversion in an HIV prevention trial. AIDS Care 2019 Jun;31(6):746-753. PMCID: PMC6594184

Marrazzo JM, Rabe L, Kelly C, Richardson B, Deal C, Schwartz JL, Chirenje ZM, Piper J, Morrow RA, Hendrix CW, Marzinke MA, Hillier SL; VOICE Study Team. Tenofovir gel for prevention of herpes simplex virus type-2 acquisition: findings from the VOICE Trial. J Infect Dis 2019 May 24;219(12):1940-1947. PMCID: PMC6534189

Sugarman J, Lin L, Baeten JM, Palanee-Phillips T, Brown ER, Matovu Kiweewa F, Mgodi NM, Nair G, Siva S, Seils DM, Weinfurt KP; MTN-020/ASPIRE Study Team. Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial. AJOB Empir Bioeth 2019 Apr-Jun;10(2):79-87. PMCID: PMC6612263

Liu AY, Zhang J, Anderson PL, Wagner T, Pan Z, Peda M, Gomez K, Beamer M, Jacobson C, Strizki J, Dezzutti CS, Piper JM; MTN-028 Protocol Team for the Microbicide Trials Network. Phase 1 Pharmacokinetic Trial of 2 Intravaginal Rings Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048. Clin Infect Dis 2019 Mar 19;68(7):1129-1135. PMCID: PMC6424086

Hoesley CJ, Chen BA, Anderson PL, Dezzutti CS, Strizki J, Sprinkle C, Heard F, Bauermeister J, Hall W, Jacobson C, Berthiaume J, Mayo A, Gundacker H, Richardson-Harman N, Piper J; Microbicide Trials Network 027 Study Team. Phase 1 Safety and Pharmacokinetics Study of MK-2048/Vicriviroc (MK-4176)/MK-2048A Intravaginal Rings. Clin Infect Dis. 2019 Mar 19;68(7):1136-1143. PMCID: PMC6424075

Chen BA, Zhang J, Gundacker HM, Hendrix CW, Hoesley CJ, Salata RA, Dezzutti CS, van der Straten A, Hall WB, Jacobson CE, Johnson S, McGowan I, Nel AM, Soto-Torres L, Marzinke MA; MTN-024/IPM 031 Protocol Team for the Microbicide Trials Network. Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women. Clin Infect Dis 2019 Mar 19;68(7):1144-1151. PMCID: PMC6424088

Myerski A, Siegel A, Engstrom J, McGowan I, Brand RM. The use of droplet digital PCR to quantify HIV-1 viral replication in the colorectal explant model. AIDS Res Hum Retroviruses 2019 Mar;35(3):326-334. PMCID: PMC6434591

Leu CS, Giguere R, Bauermeister JA, Dolezal C, Brown W 3rd, Balán IC, Richardson BA, Piper JM, Lama JR, Cranston RD, Carballo-Diéguez A. Trajectory of use over time of an oral tablet and a rectal gel for HIV prevention among transgender women and men who have sex with men. AIDS Care 2019 Mar;31(3):379-387. PMCID: PMC6382555

Noguchi LM, Hoesley C, Kelly C, Scheckter R, Bunge K, Nel A, Marzinke MA, Hendrix CW, Dezzutti CS, Hillier SL, Bogen DL, Piper JM, Beigi RH. Pharmacokinetics of dapivirine Transfer into blood plasma, breast milk, and cervicovaginal fluid of lactating women using the dapivirine vaginal ring. Antimicrob Agents Chemother 2019 Feb 26;63(3). pii: e01930-18. PMCID:PMC6395928

Kiweewa FV, Brown E, Mishra A, Nair G, Palanee-Phillips T, Mgodi N, Nakabiito C, Chakhtoura N, Hillier SL, Baeten JM, MTN-020/ASPIRE Study Team. Acquisition of Sexually Transmitted Infections among Women Using a Variety of Contraceptive Options: A Prospective Study among High-Risk African Women. J Int AIDS Soc 2019 Feb;22(2):e25257. PMCID: PMC6393855

McGowan I, Wilkin T, Landovitz RJ, Wu C, Chen Y, Marzinke MA, Hendrix CW, Richardson P, Eshleman SH, Andrade A, Chege W, Anderson PL, McCauley M, Farley J, Mayer KH, Anton P, Brand RM, Cranston RD, Gulick R. The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing pre-exposure prophylaxis regimens in MSM. AIDS 2019 Feb 1;33(2):237-246. PMCID: PMC6714572

Cranston RD, Carballo-Diéguez A, Gundacker H, Richardson BA, Giguere R, Dolezal C, Siegel A, KunjaraNaAyudhya RP, Gomez K, Piper JM, Lama JR, McGowan I; MTN-017 Protocol Team. Prevalence and determinants of anal human papillomavirus infection in men who have sex with men and transgender women. Int J STD AIDS 2019 Feb;30(2):154-162. PMCID:PMC6552657

Mensch BS, Richardson BA, Husnik M, Brown ER, Kiweewa FM, Mayo AJ, Baeten JM, Palanee-Phillips T, van der Straten A; MTN-020/ASPIRE study team. Vaginal Ring Use in a Phase 3 Microbicide Trial: A Comparison of Objective Measures and Self-reports of Non-adherence in ASPIRE. AIDS Behav 2019 Feb;23(2):504-512. PMCID: PMC6374159

Katz AWK, Mensch BS, Woeber K, Musara P, Etima J, van der Straten A. Understanding women's motivations to participate in MTN-003/VOICE, a phase 2b HIV prevention trial with low adherence. BMC Womens Health 2019 Jan 25;19(1):18. PMCID:PMC6347781

Makanani B, Balkus JE, Jiao Y, Noguchi LM, Palanee-Phillips T, Mbilizi Y, Moodley J, Kintu K, Reddy K, Kabwigu S, Jeenariain N, Harkoo I, Mgodi N, Piper J, Rees H, Scheckter R, Beigi R, Baeten JM. Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy. J Acquir Immune Defic Syndr 2018 Dec 15;79(5):566-572. PMCID: PMC6231990

Palanee-Phillips T, Roberts ST, Reddy K, Govender V, Naidoo L, Siva S, Gafoor Z, Pather A, Matovu F, Hlahla K, Makanani B, Nair G, Schwartz K, Torjesen K, Brown E, Soto-Torres L, Baeten J, Montgomery ET. Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial. J Acquir Immune Defic Syndr 2018 Dec 15;79(5):580-589. PMCID: PMC6231955

Wynne J, Muwawu R, Mubiru MC, Kamira B, Kemigisha D, Nakyanzi T, Kabwigu S, Nakabiito C, Kiweewa Matovu F. Maximizing participant retention in a phase 2B HIV prevention trial in Kampala, Uganda: The MTN-003 (VOICE) Study. HIV Clin Trials 2018 Oct;19(5):165-171. PMCID: PMC6614555

Hughes SM, Ferre AL, Yandura SE, Shetler C, Baker CAR, Calienes F, Levy CN, Astronomo RD, Shu Z, Lentz GM, Fialkow M, Kirby AC, McElrath MJ, Sinclair E, Rohan LC, Anderson PL, Shacklett BL, Dezzutti CS, Gao D, Hladik F. Cryopreservation of human mucosal tissues. PLoS One 2018 Jul 30;13(7):e0200653. PMCID:PMC6066204

Montgomery ET, Stadler J, Naidoo S, Katz AW, Laborde N, Garcia M, Reddy K, Mansoor LE, Etima J, Zimba C, Chitukuta M, Soto-Torres L. Reasons for non-adherence to the dapivirine vaginal ring: Narrative explanations of objective drug-level results. AIDS 2018 July 17; 32(11):1517-1525. PMCID: 29957723

Abbai NS, Nyirenda M, Naidoo S, Ramjee G. Prevalent Herpes Simplex Virus-2 Increases the Risk of Incident Bacterial Vaginosis in Women from South Africa. AIDS Behav 2018 Jul;22(7):2172-2180. PMCID:PMC5871553

Justman JE, Nair G, Hendrix CW, Piper JM, Marzinke MA, Dai JY, Pan Z, Galaska B, Levy L, Schwartz JL ; Balar B, Kunjara Na Ayudhya RP, Mushamiri I, McGowan I, Dezzutti CS, for the MTN-014 Study Team. Pharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study with Directly Observed Dosing. J Acquir Immune Defic Syndr 2018 Jun 1;78(2):175-182. PMCID: PMC5963717

Brown W 3rd, Giguere R, Sheinfil A, Ibitoye M, Balan I, Ho T, Brown B, Quispe L, Sukwicha W, Lama JR, Carballo-Diéguez A, Cranston RD. Challenges and Solutions Implementing an SMS Text Message-based Survey CASI and Adherence Reminders in an International Biomedical HIV PrEP Study (MTN 017). J Biomed Inform 2018 Apr;80:78-86. PMCID: PMC5920551

Giguere R, Brown Iii W, Balán IC, Dolezal C, Ho T, Sheinfil A, Ibitoye M, Lama JR, McGowan I, Cranston RD, Carballo-Diéguez A. Are participants concerned about privacy and security when using short message service to report product adherence in a rectal microbicide trial? J Am Med Inform Assoc. 2018 Apr 1;25(4):393-400. PMCID: PMC5885798

Balán IC, Giguere R, Brown W 3rd, Carballo-Diéguez A, Horn S, Hendrix CW, Marzinke MA, Ayudhya RPKN, Patterson K, Piper JM, McGowan I, Lama JR, Cranston RD; MTN-017 Protocol Team. Brief Participant-Centered Convergence Interviews Integrate Self-Reports, Product Returns, and Pharmacokinetic Results to Improve Adherence Measurement in MTN-017. AIDS Behav 2018 Mar;22(3):986-995. PMCID: PMC5983888

Musara P, Montgomery ET, Mgodi NM, Woeber K, Akello CA, Hartmann M, Cheng H, Levy L, Katz A, Grossman CI, Chirenje ZM, van der Straten A, Mensch B; Microbicide Trials Network-003D Study Team. How Presentation of Drug Detection Results Changed Reports of Product Adherence in South Africa, Uganda and Zimbabwe. AIDS Behav 2018 Mar;22(3):877-886. PMCID:PMC5587392

Laborde ND, Pleasants E, Reddy K, Atujuna M, Nakyanzi T, Chitukuta M, Naidoo S, Palanee-Phillips T, Baeten JM, Montgomery ET; MTN-020/ASPIRE Study Team. Impact of the Dapivirine Vaginal Ring on Sexual Experiences and Intimate Partnerships of Women in an HIV Prevention Clinical Trial: Managing Ring Detection and Hot Sex. AIDS Behav 2018 Feb;22(2):437-446. PMCID: PMC5866044